Surgically induced unilateral pulmonary hypertension: time-related analysis of a new experimental model

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Serval ID
serval:BIB_879FBF288B72
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Surgically induced unilateral pulmonary hypertension: time-related analysis of a new experimental model
Journal
European Journal of Cardio-Thoracic Surgery
Author(s)
Corno  A. F., Tozzi  P., Genton  C. Y., von Segesser  L. K.
ISSN
1010-7940 (Print)
Publication state
Published
Issued date
04/2003
Volume
23
Number
4
Pages
513-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
OBJECTIVE: Patients with irreversible pulmonary vascular obstructive disease caused by pulmonary hypertension due to congenital heart defects are considered either inoperable or only candidates to lung transplantation. This study evaluated an experimental model of surgically induced unilateral pulmonary hypertension. METHODS: In eight pigs, 2-months-old, the left pulmonary artery was divided at the origin and end-to-side anastomosed to the descending thoracic aorta through a left thoracotomy. In this way, increased pulmonary blood flow in the right lung and systemic perfusion pressure and oxygenation in the left lung were obtained. After an interval of 6-12 weeks the animals underwent cardiac catheterization and were then sacrificed. Histological examination was done on both the lungs. RESULTS: The mean left-to-right shunt through the left pulmonary artery diminished from 58.9+/-9.6% at the end of the procedure to 4.5+/-1.5% at the latest hemodynamic evaluation (P<0.01). Pressures and saturations remained identical in aorta and left pulmonary artery, without reduction (NS) with FiO(2)=1.0 ventilation; in the right pulmonary artery there was a mild elevation of the pressures, but still responsive (P<0.05) to FiO(2)=1.0 ventilation. Lung histology showed normal right pulmonary arteries, but irreversible vascular lesions like intimal fibrosis, medial hypertrophy, vascular occlusions, plexiform and dilatation lesions in all the left lungs. CONCLUSIONS: The lung exposed to systemic pressure and oxygenation develops irreversible vascular lesions typical of pulmonary vascular obstructive disease. The lung exposed to increased flow shows only mild elevation of the arterial pressure, remains responsive to oxygen vasodilatation, and displays normal histology.
Keywords
Animals *Hypertension, Pulmonary/pathology/physiopathology Lung/physiopathology *Models, Animal Pulmonary Artery/pathology *Swine Time Factors Vascular Resistance
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 9:42
Last modification date
25/09/2019 6:09
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