¹⁸F-FDG uptake as a prognostic variable in primary differentiated thyroid cancer incidentally detected by PET/CT: a multicentre study.

Details

Serval ID
serval:BIB_876C322B4ACA
Type
Article: article from journal or magazin.
Collection
Publications
Title
¹⁸F-FDG uptake as a prognostic variable in primary differentiated thyroid cancer incidentally detected by PET/CT: a multicentre study.
Journal
European journal of nuclear medicine and molecular imaging
Author(s)
Piccardo A., Puntoni M., Bertagna F., Treglia G., Foppiani L., Arecco F., Giubbini R., Naseri M., Cistaro A., Cabria M., Bardesono F., Ceriani L., Orlandi F., Giovanella L.
ISSN
1619-7089 (Electronic)
ISSN-L
1619-7070
Publication state
Published
Issued date
08/2014
Peer-reviewed
Oui
Volume
41
Number
8
Pages
1482-1491
Language
english
Notes
Publication types: Evaluation Studies ; Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Our aim was to investigate the association between (18)F-fluorodeoxyglucose (FDG) uptake and event-free survival in patients in whom a differentiated thyroid cancer (DTC) was detected by (18)F-FDG positron emission tomography (PET)/CT.
Among 884 focal (18)F-FDG PET thyroid incidentalomas referred to our 4 Nuclear Medicine Departments, we investigated 54 patients in whom a DTC was confirmed and a clinical follow-up was available. The ratio between maximum standardized uptake value (SUVmax) of DTC and SUVmean of the liver (SUV ratio) was recorded for each scan. All patients underwent total thyroidectomy and (131)I remnant ablation. After a median follow-up of 39 months we assessed the outcome. The association between disease persistence/progression, (18)F-FDG uptake and other risk factors (T, N, M and histological subtype) was evaluated through univariate and multivariate analyses.
Of the 54 patients, 39 achieved complete remission. The remaining 15 showed persistence/progression of disease. High (18)F-FDG uptake, i.e. SUV ratio ≥3, showed a low positive predictive value (48 %). Low (18)F-FDG uptake (SUV ratio < 3) displayed a high negative predictive value (93 %). The median of SUV ratios in T1-T2 (2.2), in M0 (2.7) and in non-virulent subtypes (2.7) were significantly lower (p < 0.03) than in T3-T4 (5.0), M1 (7.3) and virulent subtypes (6.0). Kaplan-Maier analysis showed a significant association between high (18)F-FDG uptake and disease persistence/progression (p = 0.001). When we adjusted risk estimates by using a multivariate Cox model, only T (p = 0.05) remained independently associated with disease persistence/progression.
An intense (18)F-FDG uptake of the primary DTC is associated with persistence/progression of disease. However, when all other prognostic factors have been taken into account, (18)F-FDG uptake does not add further prognostic information.

Keywords
Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Fluorodeoxyglucose F18, Humans, Incidental Findings, Male, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Predictive Value of Tests, Radiopharmaceuticals, Thyroid Neoplasms/diagnostic imaging, Tomography, X-Ray Computed
Pubmed
Web of science
Create date
20/08/2017 19:19
Last modification date
03/03/2018 19:01
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