All-polymeric transient neural probe for prolonged in-vivo electrophysiological recordings.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_875E2ACBBFD4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
All-polymeric transient neural probe for prolonged in-vivo electrophysiological recordings.
Journal
Biomaterials
Author(s)
Ferlauto L., Vagni P., Fanelli A., Zollinger E.G., Monsorno K., Paolicelli R.C., Ghezzi D.
ISSN
1878-5905 (Electronic)
ISSN-L
0142-9612
Publication state
Published
Issued date
07/2021
Peer-reviewed
Oui
Volume
274
Pages
120889
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Transient bioelectronics has grown fast, opening possibilities never thought before. In medicine, transient implantable devices are interesting because they could eliminate the risks related to surgical retrieval and reduce the chronic foreign body reaction. Despite recent progress in this area, the potential of transient bioelectronics is still limited by their short functional lifetime owed to the fast dissolution rate of degradable metals, which is typically a few days or weeks. Here we report that a switch from degradable metals to an entirely polymer-based approach allows for a slower degradation process and a longer lifetime of the transient probe, thus opening new possibilities for transient medical devices. As a proof-of-concept, we fabricated all-polymeric transient neural probes that can monitor brain activity in mice for a few months, rather than a few days or weeks. Also, we extensively evaluated the foreign body reaction around the implant during the probe degradation. This kind of devices might pave the way for several applications in neuroprosthetics.
Keywords
Animals, Electrophysiological Phenomena, Mice, Polymers, Prostheses and Implants
Pubmed
Web of science
Open Access
Yes
Create date
29/05/2021 16:27
Last modification date
20/07/2022 6:37
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