Thalamic reticular control of local sleep in mouse sensory cortex.

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State: Public
Version: Final published version
Serval ID
serval:BIB_872EE93FB4BC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thalamic reticular control of local sleep in mouse sensory cortex.
Journal
eLife
Author(s)
Fernandez L.M., Vantomme G., Osorio-Forero A., Cardis R., Béard E., Lüthi A.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
25/12/2018
Peer-reviewed
Oui
Volume
7
Pages
e39111
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due to higher activity of the low-threshold Ca <sup>2+</sup> channel Ca <sub>V</sub> 3.3. Major NREMS rhythms in sensory but not non-sensory cortical areas were regulated in a Ca <sub>V</sub> 3.3-dependent manner. In particular, NREMS in somatosensory cortex was enriched in fast spindles, but switched to delta wave-dominated sleep when Ca <sub>V</sub> 3.3 channels were genetically eliminated or somatosensory TRN cells chemogenetically hyperpolarized. Our data indicate a previously unrecognized heterogeneity in a powerful forebrain oscillator that contributes to sensory-cortex-specific and dually regulated NREMS, enabling local sleep regulation according to use- and experience-dependence.
Keywords
Action Potentials, Animals, Brain Waves, Calcium Channels, T-Type/metabolism, Mice, Optogenetics, Sleep, Somatosensory Cortex/physiology, Thalamic Nuclei/physiology, Ca2+ channel, EEG, LFP, mouse, neuroscience, schizophrenia, sleep spindles, spectral power
Pubmed
Web of science
Open Access
Yes
Create date
08/01/2019 7:49
Last modification date
20/08/2019 14:46
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