Compartments within human primary auditory cortex: evidence from cytochrome oxidase and acetylcholinesterase staining.

Details

Serval ID
serval:BIB_8724
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Compartments within human primary auditory cortex: evidence from cytochrome oxidase and acetylcholinesterase staining.
Journal
European Journal of Neuroscience
Author(s)
Clarke S., Rivier F.
ISSN
0953-816X
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
10
Number
2
Pages
741-5
Language
english
Abstract
The human primary auditory area (AI) corresponds to granular cortex located on Heschl's gyrus. We studied its pattern of cytochrome oxidase and acetylcholinesterase activity in 10 normal human hemispheres. In cytochrome-oxidase-stained coronal sections layer IV was prominent by its dark staining. The overall staining intensity varied along the medio-lateral extent of Al; a 2.0-2.5-mm-wide antero-posterior dark band was present at mid-AI. In acetylcholinesterase-stained coronal sections a dark antero-posterior band appeared at the same location, corresponding to the highly granular part of Al. In cytochrome-oxidase-stained tangential sections of flattened Al, approximately 500-microm thick alternating dark and light cytochrome oxidase stripes were present in layers III and IV. These stripes were perpendicular to the dark band. Comparison with tonotopic maps of human Al obtained by activation studies suggests that the cytochrome oxidase and acetylcholinesterase dark band is most likely parallel to isofrequency lines and may correspond to the representation of frequencies critical for speech comprehension. The narrow stripes may be related to particular binaural or ampliotopic domains, whose presence is suggested by evidence from electrophysiological recordings in cat Al and from magnetoencephalographic studies in humans.
Keywords
Acetylcholinesterase, Aged, Aged, 80 and over, Auditory Cortex, Electron Transport Complex IV, Female, Humans, Immunohistochemistry, Male
Pubmed
Web of science
Create date
19/11/2007 12:47
Last modification date
20/08/2019 14:46
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