Blockade of the vascular effect of vasopressin in patients with mild essential hypertension

Details

Serval ID
serval:BIB_8718674EDDB0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Blockade of the vascular effect of vasopressin in patients with mild essential hypertension
Journal
Archives Internationales de Pharmacodynamie et de Therapie
Author(s)
Bussien  J. P., Waeber  B., Nussberger  J., Hofbauer  K. G., Brunner  H. R.
ISSN
0767-3981
0301-4533 (Print)
Publication state
Published
Issued date
07/1986
Volume
282
Number
1
Pages
130-9
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jul
Abstract
The effect of circulating arginine vasopressin (AVP) on blood pressure, heart rate and skin blood flow was investigated in 8 untreated patients with mild essential hypertension using a specific antagonist of the pressor effect of AVP. Skin blood flow was measured with a laser Doppler flowmeter and blood pressure with a Remler M2000 recorder. The study was carried out in double-blind fashion using a cross-over design. Each patient received at a 60 min interval the AVP-antagonist, d(CH2)5Tyr(Me) AVP, 5 micrograms/kg i.v., and its vehicle. The sequence of treatment phases was randomly allocated. Pretreatment plasma AVP levels averaged 1.1 +/- 0.2 pg/ml (mean +/- SEM). Neither the AVP-antagonist nor its vehicle had any effect on blood pressure, heart rate and skin blood flow as well as on plasma renin activity and plasma catecholamines. It is therefore concluded that circulating AVP does not contribute to the maintenance of blood pressure in patients with mild essential hypertension and normal plasma AVP levels.
Keywords
Adult Arginine Vasopressin/*analogs & derivatives/*antagonists & inhibitors/blood/pharmacology Blood Pressure/drug effects Female Heart Rate/drug effects Hemodynamic Processes/*drug effects Humans Hypertension/*physiopathology Male Middle Aged Osmolar Concentration Regional Blood Flow/drug effects
Pubmed
Web of science
Create date
05/03/2008 16:41
Last modification date
20/08/2019 14:46
Usage data