The frequency of severe Fetal Alcohol Spectrum Disorders in the neonatal period using data from the French hospital discharge database between 2006 and 2013.

Details

Serval ID
serval:BIB_8712359F98BE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The frequency of severe Fetal Alcohol Spectrum Disorders in the neonatal period using data from the French hospital discharge database between 2006 and 2013.
Journal
Drug and alcohol dependence
Author(s)
Demiguel V., Laporal S., Quatremere G., Barry Y., Guseva Canu I., Goulet V., Germanaud D., Regnault N.
ISSN
1879-0046 (Electronic)
ISSN-L
0376-8716
Publication state
Published
Issued date
01/08/2021
Peer-reviewed
Oui
Volume
225
Pages
108748
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
At birth, only complete Fetal Alcohol Syndrome (FAS) can be properly diagnosed. However, other Consequences of prenatal Alcohol Exposure (CAE) can also be recorded. Our objective was to describe the frequency of diagnoses highly suggestive of "potential Fetal Alcohol Syndrome Disorder" (pFASD, i.e., FAS and CAE) among hospitalized neonates, during the neonatal period, in France, between 2006 and 2013.
We used the French national hospital discharge database to identify the Q86.0 (FAS) and P04.3 (CAE) ICD-10 codes in hospital stays occurring in the first 28 days of life. FAS, CAE and pFASD rates were estimated per 1000 live births at the national level for the 2009-2013 period. We compared the 2006-2009 and 2010-2013 rates. The pFASD rates were also estimated at the regional level.
Overall, 3,207 cases of pFASD were diagnosed during the neonatal period (i.e., 0.48 cases per 1000 live births, including 0.07 cases of FAS per 1000). Between 2006-2009 and 2010-2013, pFASD remained stable, despite a moderate decrease in reported FAS (0.08 vs 0.06 cases per 1000, p < 0.001). At the regional level, pFASD rates varied between 0.13 and 1.22 cases per 1000.
This study provides the first national estimate of neonatal diagnosis of FAS, and more broadly pFASD, in France. Although our data certainly underestimate the real prevalence of FASD, they provide a minimal estimate of the burden of alcohol use during pregnancy. Observed variations deserve to be analyzed in the light of concomitant prevention and public information campaigns.
Keywords
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, International Classification of Diseases, Neonatal period, Prenatal alcohol exposure
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2021 14:49
Last modification date
22/01/2022 7:33
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