Disseminated histoplasmosis in an adopted infant from El Salvador.

Details

Serval ID
serval:BIB_86FC0D98D30B
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Disseminated histoplasmosis in an adopted infant from El Salvador.
Journal
European Journal of Pediatrics
Author(s)
Troillet N., Llor J., Kuchler H., Delèze G., Praz G.
ISSN
0340-6199 (Print)
ISSN-L
0340-6199
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
155
Number
6
Pages
474-476
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
An HIV-negative 4-month-old infant recently adopted from El Salvador was admitted for high fever. Hepatosplenomegaly, anaemia, leucopenia, thrombocytopenia, increased transaminases, and diffuse interstitial pulmonary infiltration were present on admission. Granulomas were seen in bone marrow and liver biopsies without any organism. Disseminated histoplasmosis was diagnosed 2 weeks later when bone marrow and blood cultures taken on admission became positive for Histoplasma capsulatum and when histoplasmic antigen was detected in blood. The outcome was good after treatment with amphotericin B followed by itraconazole which was administered for a 6-month period without significant toxicity.
CONCLUSION: Disseminated histoplasmosis is very rarely seen in Europe but should be suspected in case of unexplained fever in immigrants from the endemic areas in the world, particularly when hepatosplenomegaly and pancytopenia are present. Bone marrow examination and culture, blood cultures, and antigen testing are the mainstays of the diagnosis.
Keywords
Adoption, Antifungal Agents/therapeutic use, Biopsy, Needle, Bone Marrow/pathology, El Salvador/ethnology, Fungemia/diagnosis, Fungemia/drug therapy, Histoplasmosis/diagnosis, Histoplasmosis/drug therapy, Humans, Infant, Itraconazole/therapeutic use, Lung Diseases, Fungal/diagnosis, Lung Diseases, Fungal/drug therapy, Male, Switzerland
Pubmed
Create date
28/12/2013 17:54
Last modification date
20/08/2019 14:46
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