Control of vascular tone by renin and angiotensin in cardiovascular disease

Details

Serval ID
serval:BIB_86E03638A51C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Control of vascular tone by renin and angiotensin in cardiovascular disease
Journal
European Heart Journal
Author(s)
Brunner  H. R., Nussberger  J., Waeber  B.
ISSN
0195-668X (Print)
Publication state
Published
Issued date
11/1993
Volume
14 Suppl I
Pages
149-53
Notes
Journal Article
Review --- Old month value: Nov
Abstract
The tools which have led to a better understanding of the role of the renin-angiotensin system in determining the tone of peripheral arteries in cardiovascular disease consist of highly specific and sensitive methods to measure the different components of the renin-angiotensin system and in specific probes used to inhibit the renin-angiotensin system at several points of the enzymatic cascade. The therapeutic efficacy of these more and more specific probes undoubtedly provides strong circumstantial evidence that angiotensin II plays an important role in determining peripheral vascular tone. While this has considerably increased our understanding of the regulatory mechanism involved in blood pressure maintenance in normotensive subjects and hypertensive patients, the role of the renin-angiotensin system as an aetiological factor in the development of essential hypertension still remains unclear.
Keywords
Angiotensin II/antagonists & inhibitors/drug effects Angiotensin-Converting Enzyme Inhibitors/pharmacology Humans Hypertension/*physiopathology Renin/antagonists & inhibitors/physiology Renin-Angiotensin System/*physiology
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 14:46
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