Depression in Parkinson's disease.

Details

Serval ID
serval:BIB_86DF18061E09
Type
Article: article from journal or magazin.
Collection
Publications
Title
Depression in Parkinson's disease.
Journal
Canadian Journal of Neurological Sciences
Author(s)
Jasinska-Myga B., Putzke J.D., Wider C., Wszolek Z.K., Uitti R.J.
ISSN
0317-1671[print], 0317-1671[linking]
Publication state
Published
Issued date
2010
Volume
37
Number
1
Pages
61-66
Language
english
Abstract
OBJECTIVE: To examine predictive factors associated with onset of depression among individuals diagnosed with Parkinson's disease (PD).
BACKGROUND: Depression may precede or follow symptomatic parkinsonism in PD. It is frequently treatable but often overlooked.
METHODS: The clinical series comprised 685 individuals who were diagnosed with PD and followed by one neurologist (RJU) from 1994 to 2007. The primary outcome was time to depression following the onset of PD. Diagnosis of depression was based on clinical assessment of depressive symptoms from patients (and spouse/family/caregiver) and antidepressant usage. A number of demographic, historical and clinical predictive factors were examined, including gender, age at symptomatic onset, disease duration, onset characteristics, clinical ratings, antiparkinsonian medications, cognitive status, depression history, and familial history of PD and other neurodegenerative disorders.
RESULTS: Seventy-two percent of patients developed depression within ten years of symptomatic PD onset, and the mean time to depression was 7.9 years (median: 5.7 years). Factors associated with depression included longer PD duration, greater impairment in activities of daily living, and positive family history of motor neuron disease (MND).
CONCLUSIONS: A high rate of individuals with PD develop depressive symptoms during the course of the disease. Based on first clinic visit characteristics, most factors examined were not helpful in identifying individuals with an increased risk of depression. However, disease duration, functional limitations and family history of MND should lead clinicians to an increased vigilance for identifying depression.
Keywords
Age Factors, Age of Onset, Aged, Aged, 80 and over, Antiparkinson Agents/therapeutic use, Depression/complications, Depression/mortality, Female, Follow-Up Studies, Humans, Male, Parkinson Disease/complications, Parkinson Disease/drug therapy, Predictive Value of Tests, Retrospective Studies, Sex Factors, Survival Analysis
Pubmed
Create date
24/09/2010 17:57
Last modification date
20/08/2019 14:46
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