Evaluation of occupational exposure: comparison of biological and environmental variabilities using physiologically based toxicokinetic modeling

Details

Serval ID
serval:BIB_86CED6BA0041
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of occupational exposure: comparison of biological and environmental variabilities using physiologically based toxicokinetic modeling
Journal
International Archives of Occupational and Environmental Health
Author(s)
Truchon Ginette, Tardif Robert, Charest-Tardif Ginette, de Batz Alice, Droz Pierre-Olivier
ISSN
1432-1246 (Electronic)
ISSN-L
0340-0131
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
86
Number
2
Pages
157-165
Language
english
Notes
Publication types: JOURNAL ARTICLE
Abstract
PURPOSE: Few studies compare the variabilities that characterize environmental (EM) and biological monitoring (BM) data. Indeed, comparing their respective variabilities can help to identify the best strategy for evaluating occupational exposure. The objective of this study is to quantify the biological variability associated with 18 bio-indicators currently used in work environments. METHOD: Intra-individual (BV(intra)), inter-individual (BV(inter)), and total biological variability (BV(total)) were quantified using validated physiologically based toxicokinetic (PBTK) models coupled with Monte Carlo simulations. Two environmental exposure profiles with different levels of variability were considered (GSD of 1.5 and 2.0). RESULTS: PBTK models coupled with Monte Carlo simulations were successfully used to predict the biological variability of biological exposure indicators. The predicted values follow a lognormal distribution, characterized by GSD ranging from 1.1 to 2.3. Our results show that there is a link between biological variability and the half-life of bio-indicators, since BV(intra) and BV(total) both decrease as the biological indicator half-lives increase. BV(intra) is always lower than the variability in the air concentrations. On an individual basis, this means that the variability associated with the measurement of biological indicators is always lower than the variability characterizing airborne levels of contaminants. For a group of workers, BM is less variable than EM for bio-indicators with half-lives longer than 10-15 h. CONCLUSION: The variability data obtained in the present study can be useful in the development of BM strategies for exposure assessment and can be used to calculate the number of samples required for guiding industrial hygienists or medical doctors in decision-making.
Pubmed
Web of science
Create date
30/03/2012 11:23
Last modification date
20/08/2019 14:46
Usage data