Leveraging the immune system during chemotherapy: moving calreticulin to the cell surface converts apoptotic death from "silent" to immunogenic.

Details

Serval ID
serval:BIB_86C81A685CC8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Leveraging the immune system during chemotherapy: moving calreticulin to the cell surface converts apoptotic death from "silent" to immunogenic.
Journal
Cancer research
Author(s)
Obeid M., Panaretakis T., Tesniere A., Joza N., Tufi R., Apetoh L., Ghiringhelli F., Zitvogel L., Kroemer G.
ISSN
0008-5472 (Print)
ISSN-L
0008-5472
Publication state
Published
Issued date
01/09/2007
Peer-reviewed
Oui
Volume
67
Number
17
Pages
7941-7944
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
In contrast to prior belief, tumor cell apoptosis is not necessarily silent but can be immunogenic. By tracing how anthracyclines and gamma-irradiation trigger immunogenic cell deaths, we found that they were causally connected to the exposure of calreticulin on the tumor cell surface, before apoptosis in the tumor cell itself occurred. Furthermore, we showed that calreticulin exposure was necessary and sufficient to increase proimmunogenic killing by other chemotherapies. Our findings suggest that calreticulin could serve as a biomarker to predict therapy-associated immune responses, and that tactics to expose calreticulin might improve the clinical efficacy of many cancer therapies.

Keywords
Animals, Antigens, Surface/metabolism, Antineoplastic Combined Chemotherapy Protocols/pharmacology, Apoptosis/drug effects, Apoptosis/immunology, Calreticulin/metabolism, Cell Death/drug effects, Humans, Immune System/drug effects, Models, Biological
Pubmed
Web of science
Open Access
Yes
Create date
13/09/2017 17:37
Last modification date
20/08/2019 14:46
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