Effect of ganglion blockade with pentolinium on circulating neuropeptide Y levels in conscious rats.

Details

Serval ID
serval:BIB_86B30489F549
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of ganglion blockade with pentolinium on circulating neuropeptide Y levels in conscious rats.
Journal
Journal of cardiovascular pharmacology
Author(s)
Corder R., Waeber B., Evequoz D., Nussberger J., Gaillard R., Brunner H.
ISSN
0160-2446
Publication state
Published
Issued date
1988
Peer-reviewed
Oui
Volume
12
Number
2
Pages
140-3
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
The vasoconstrictor peptide, neuropeptide Y (NPY), is present in perivascular noradrenergic neurons of all mammals studied and may be important in the regulation of blood pressure. High plasma levels of NPY have been measured in the rat. To investigate partially the source and factors controlling the release of the circulating peptide, the effect of pentolinium tartrate administration has been studied in conscious rats. Pentolinium given as a bolus (5 mg/kg) followed by an infusion of a further 5 mg/kg/30 min produced a highly significant reduction in blood pressure of more than 40 mm Hg, when compared to either basal values or control animals treated with saline. Pentolinium treatment resulted in significantly lower plasma neuropeptide Y levels (31.0 +/- 6.7 fmol/ml) compared with those of control animals (78.6 +/- 8.2 fmol/ml). Circulating catecholamines were also significantly reduced in those animals receiving pentolinium. These results are compatible with circulating NPY arising from the sympathetic nervous system, with release being controlled by the mechanisms already established for catecholamines.
Keywords
Animals, Blood Pressure, Ganglionic Blockers, Heart Rate, Male, Neuropeptide Y, Pentolinium Tartrate, Rats, Rats, Inbred Strains
Pubmed
Web of science
Create date
05/03/2008 16:40
Last modification date
20/08/2019 14:46
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