Antioxidant actions of ovothiol-derived 4-mercaptoimidazoles: glutathione peroxidase activity and protection against peroxynitrite-induced damage.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_86AD25F7C4AC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Antioxidant actions of ovothiol-derived 4-mercaptoimidazoles: glutathione peroxidase activity and protection against peroxynitrite-induced damage.
Journal
FEBS letters
Author(s)
Bailly F., Zoete V., Vamecq J., Catteau J.P., Bernier J.L.
ISSN
0014-5793 (Print)
ISSN-L
0014-5793
Publication state
Published
Issued date
01/12/2000
Peer-reviewed
Oui
Volume
486
Number
1
Pages
19-22
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
4-Mercaptoimidazoles derived from the naturally occurring antioxidants, ovothiols, were tested for their glutathione peroxidase-like (GSH Px-like) activity and protection against peroxynitrite-induced damage. All the thiol compounds displayed similar significant GSH Px-like activities, which are however weaker than that of the reference compound, ebselen. The inhibitions of the peroxynitrite-dependent oxidation of Evans blue dye and dihydrorhodamine 123 showed that the thiol compounds substituted on position 5 of the imidazole ring were nearly as effective as ebselen while the C-2 substituted ones were less effective. Both assays corroborate the large superiority of mercaptoimidazoles over glutathione as inhibitors of peroxynitrite-dependent oxidation.
Keywords
Antioxidants/chemistry, Antioxidants/metabolism, Antioxidants/pharmacology, Azoles/metabolism, Azoles/pharmacology, Catalysis/drug effects, Chromans/metabolism, Chromans/pharmacology, Evans Blue/metabolism, Free Radical Scavengers/metabolism, Free Radical Scavengers/pharmacology, Glutathione/metabolism, Glutathione/pharmacology, Glutathione Peroxidase/metabolism, Hydrogen Peroxide/metabolism, Imidazoles/chemistry, Imidazoles/metabolism, Imidazoles/pharmacology, Inhibitory Concentration 50, Kinetics, Methylhistidines/metabolism, NADP/metabolism, Nitrates/antagonists & inhibitors, Nitrates/metabolism, Nitrates/pharmacology, Organoselenium Compounds/metabolism, Organoselenium Compounds/pharmacology, Oxidants/antagonists & inhibitors, Oxidants/metabolism, Oxidants/pharmacology, Oxidation-Reduction/drug effects, Rhodamines/metabolism, Sulfhydryl Compounds/chemistry, Sulfhydryl Compounds/metabolism, Sulfhydryl Compounds/pharmacology
Pubmed
Web of science
Create date
22/01/2019 10:39
Last modification date
21/08/2019 5:37
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