Methods for evaluating endothelial function: a position statement from the European Society of Cardiology Working Group on Peripheral Circulation.

Details

Serval ID
serval:BIB_86A6B2A9B0A1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Methods for evaluating endothelial function: a position statement from the European Society of Cardiology Working Group on Peripheral Circulation.
Journal
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
Author(s)
Lekakis J., Abraham P., Balbarini A., Blann A., Boulanger C.M., Cockcroft J., Cosentino F., Deanfield J., Gallino A., Ikonomidis I., Kremastinos D., Landmesser U., Protogerou A., Stefanadis C., Tousoulis D., Vassalli G., Vink H., Werner N., Wilkinson I., Vlachopoulos C.
ISSN
1741-8275 (Electronic)
ISSN-L
1741-8267
Publication state
Published
Issued date
12/2011
Peer-reviewed
Oui
Volume
18
Number
6
Pages
775-789
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The endothelium holds a pivotal role in cardiovascular health and disease. Assessment of its function was until recently limited to experimental designs due to its location. The advent of novel techniques has facilitated testing on a more detailed basis, with focus on distinct pathways. This review presents available in-vivo and ex-vivo methods for evaluating endothelial function with special focus on more recent ones. The diagnostic modalities covered include assessment of epicardial and microvascular coronary endothelial function, local vasodilation by venous occlusion plethysmography and flow-mediated dilatation, arterial pulse wave analysis and pulse amplitude tonometry, microvascular blood flow by laser Doppler flowmetry, biochemical markers and bioassays, measurement of endothelial-derived microparticles and progenitor cells, and glycocalyx measurements. Insights and practical information on the theoretical basis, methodological aspects, and clinical application in various disease states are discussed. The ability of these methods to detect endothelial dysfunction before overt cardiovascular disease manifests make them attractive clinical tools for prevention and rehabilitation.

Keywords
Animals, Biomarkers/analysis, Cardiology, Cardiovascular Diseases/blood, Cardiovascular Diseases/diagnosis, Cardiovascular Diseases/physiopathology, Diagnostic Techniques, Cardiovascular, Endothelium, Vascular/metabolism, Endothelium, Vascular/physiopathology, Europe, Hemodynamics, Humans, Predictive Value of Tests, Prognosis, Societies, Medical
Pubmed
Create date
15/12/2016 13:34
Last modification date
20/08/2019 14:45
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