The major secreted antigen complex (Ag 85) from Mycobacterium bovis bacille Calmette-Guérin is associated with protective T cells in leprosy: a follow-up study of 45 household contacts.

Details

Serval ID
serval:BIB_869F2F1EAE11
Type
Article: article from journal or magazin.
Collection
Publications
Title
The major secreted antigen complex (Ag 85) from Mycobacterium bovis bacille Calmette-Guérin is associated with protective T cells in leprosy: a follow-up study of 45 household contacts.
Journal
Journal of Infectious Diseases
Author(s)
Launois P., Niang M.N., De Bruyn J., Sarthou J.L., Rivier F., Drowart A., Van Vooren J.P., Millan J., Huygen K.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
1993
Volume
167
Number
5
Pages
1160-1167
Language
english
Abstract
T cell proliferation and interferon (IFN)-gamma secretion were analyzed in 45 leprosy contacts stimulated with antigen 85 (Ag85), the major culture filtrate antigen from Mycobacterium bovis bacille Calmette-Guérin. All 14 Mitsuda reaction-positive contacts reacted to Mycobacterium leprae and Ag85. Three Mitsuda reaction-negative contacts reacted weakly to M. leprae and Ag85. The other 28 Mitsuda reaction-negative contacts did not react to M. leprae, but 9 reacted to Ag85. Thirty-four contacts were retested 16 months later. Eleven contacts initially positive by the Mitsuda test remained lepromin positive and reactive to M. leprae and Ag85. Fourteen contacts initially negative by the Mitsuda test converted, and all reacted in vitro to M. leprae and Ag85. Finally, 9 contacts remained Mitsuda test-negative, and 7 were unreactive to Ag85. In vitro reactivity to Ag85 at baseline in Mitsuda test-negative contacts was associated with subsequent conversion to lepromin reactivity in 7 of 9 subjects. These data suggest that reactive T cells against Ag85 develop very early during M. leprae infection and that Ag85 is a potentially protective T cell immunogen.
Keywords
Adolescent, Adult, Animals, Antigens, Bacterial/immunology, Armadillos, Female, Follow-Up Studies, Humans, Leprosy/immunology, Male, Mycobacterium bovis/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Create date
28/01/2008 11:06
Last modification date
20/08/2019 14:45
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