Early Rebleeding after Brain Arteriovenous Malformation Rupture, Clinical Impact and Predictive Factors: A Monocentric Retrospective Cohort Study.

Details

Serval ID
serval:BIB_867DBE2E9291
Type
Article: article from journal or magazin.
Collection
Publications
Title
Early Rebleeding after Brain Arteriovenous Malformation Rupture, Clinical Impact and Predictive Factors: A Monocentric Retrospective Cohort Study.
Journal
Cerebrovascular diseases
Author(s)
Shotar E., Pistocchi S., Haffaf I., Bartolini B., Jacquens A., Nouet A., Chiras J., Degos V., Sourour N.A., Clarençon F.
ISSN
1421-9786 (Electronic)
ISSN-L
1015-9770
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
44
Number
5-6
Pages
304-312
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Brain arteriovenous malformations (BAVMs) are a leading cause of intracranial hemorrhage in young adults. This study aimed to identify individual predictive factors of early rebleeding after BAVM rupture and determine its impact on prognosis.
Early rebleeding was defined as a spontaneous intracranial hemorrhage within 30 days of BAVM rupture in patients with nonobliterated BAVMs. One hundred fifty one patients with 158 BAVM hemorrhagic events admitted to a tertiary care center during 14 years were included. Univariate followed by multivariate logistic regression was performed to assess the impact of early rebleeding on in-hospital mortality and modified Rankin Scale (mRS) score beyond 3 months and to identify independent predictors of early rebleeding.
Eight early rebleeding events were observed, 6 of which occurred during the first 7 days. Early rebleeding was independently and significantly associated with poor outcome (mRS ≥3 beyond 3 months, p = 0.004) but not with in-hospital mortality (p = 0.9). Distal flow-related aneurysms (p = 0.009) and altered consciousness with a Glasgow coma scale score of 3 (p = 0.01) were independently associated with early rebleeding.
Early rebleeding is a severe complication that can occur after BAVM-related hemorrhage. Distal flow-related aneurysms and initial altered consciousness are associated with early rebleeding.

Keywords
Aneurysm, Arteriovenous malformation, Intracranial hemorrhage, Outcome, Stroke
Pubmed
Web of science
Create date
13/10/2017 13:18
Last modification date
20/08/2019 14:45
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