Paper 4: EUROCAT statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europe.

Details

Serval ID
serval:BIB_867A278B0D0F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Paper 4: EUROCAT statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europe.
Journal
Birth Defects Research. Part A, Clinical and Molecular Teratology
Author(s)
Loane M., Dolk H., Kelly A., Teljeur C., Greenlees R., Densem J.
Working group(s)
EUROCAT Working Group
ISSN
1542-0760 (Electronic)
ISSN-L
1542-0752
Publication state
Published
Issued date
03/2011
Volume
91
Number
Suppl. 1
Pages
S31-S43
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Investigators List: Haeusler (Martin) M ; Nelen (Vera) V ; Verellen-Dumoulin (Christine) C ; Barisic (Ingeborg) I ; Garne (Ester) E ; Randrianaivo (Hanitra) H ; Doray (Berenice) B ; Queisser-Luft (Annette) A ; Rissmann (Anke) A ; O'Mahony (Mary) M ; McDonnell (Bob) B ; Mullaney (Carmel) C ; Calzolari (Elisa) E ; Romagna (Emilia) E ; Bianchi (Fabrizio) F ; Gatt (Miriam) M ; Bakker (Marian) M ; Melve (Kari Klungsoyr) KK ; Latos-Bielenska (Anna) A ; Dias (Carlos Matias) CM ; Salvador (Joaquin) J ; Arriola (Larraitz) L ; Addor (Marie-Claude) MC ; Wertelecki (Wladimir) W ; Draper (Elizabeth) E ; Rankin (Judith) J ; Boyd (Patricia) P ; Tucker (David) D ; Wellesley (Diana) D ;
Abstract
BACKGROUND: As part of EUROCAT's surveillance of congenital anomalies in Europe, a statistical monitoring system has been developed to detect recent clusters or long-term (10 year) time trends. The purpose of this article is to describe the system for the identification and investigation of 10-year time trends, conceived as a "screening" tool ultimately leading to the identification of trends which may be due to changing teratogenic factors.METHODS: The EUROCAT database consists of all cases of congenital anomalies including livebirths, fetal deaths from 20 weeks gestational age, and terminations of pregnancy for fetal anomaly. Monitoring of 10-year trends is performed for each registry for each of 96 non-independent EUROCAT congenital anomaly subgroups, while Pan-Europe analysis combines data from all registries. The monitoring results are reviewed, prioritized according to a prioritization strategy, and communicated to registries for investigation. Twenty-one registries covering over 4 million births, from 1999 to 2008, were included in monitoring in 2010.CONCLUSIONS: Significant increasing trends were detected for abdominal wall anomalies, gastroschisis, hypospadias, Trisomy 18 and renal dysplasia in the Pan-Europe analysis while 68 increasing trends were identified in individual registries. A decreasing trend was detected in over one-third of anomaly subgroups in the Pan-Europe analysis, and 16.9% of individual registry tests. Registry preliminary investigations indicated that many trends are due to changes in data quality, ascertainment, screening, or diagnostic methods. Some trends are inevitably chance phenomena related to multiple testing, while others seem to represent real and continuing change needing further investigation and response by regional/national public health authorities.
Keywords
Biometry, Chromosomes, Human, Pair 18, Congenital Abnormalities/epidemiology, Databases, Factual/trends, Type="Geographic">Europe/epidemiology, Female, Fetal Death/epidemiology, Gastroschisis/epidemiology, Guidelines as Topic, Humans, Hypospadias/epidemiology, Kidney Diseases/epidemiology, Male, Population Surveillance, Pregnancy, Prevalence, Registries/statistics & numerical data, Teratogens, Trisomy
Pubmed
Web of science
Open Access
Yes
Create date
16/02/2012 11:41
Last modification date
20/08/2019 14:45
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