Prevalence of functional (psychogenic) parkinsonism in two Swiss movement disorders clinics and review of the literature.

Details

Serval ID
serval:BIB_8675F0ADE363
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence of functional (psychogenic) parkinsonism in two Swiss movement disorders clinics and review of the literature.
Journal
Journal of the neurological sciences
Author(s)
Frasca Polara G., Fleury V., Stone J., Barbey A., Burkhard P.R., Vingerhoets F., Aybek S.
ISSN
1878-5883 (Electronic)
ISSN-L
0022-510X
Publication state
Published
Issued date
15/04/2018
Peer-reviewed
Oui
Volume
387
Pages
37-45
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Functional parkinsonism (FP) is considered rare but no studies have looked at its frequency. Case series have described high rates of comorbidity with Parkinson's disease (PD), suggesting a possible association between these conditions.
To study the prevalence, epidemiology and clinical features of FP and its association with PD.
We conducted a cross-sectional population-based prevalence study as well as a chart review of cases who received a diagnosis of FP over a 10-year-period in two movement disorder clinics in Switzerland. Epidemiological data regarding FP features were collected. The co-occurrence of PD, psychiatric disorders and other functional disorders were recorded. Clinical differences between FP and FP+PD groups are presented and discussed in light of a literature review.
The crude prevalence of FP was 0.64 per 100,000 in our population. FP represented 0.24% of patients with parkinsonism. Among 12 FP cases, female gender predominance (87%), mean age of onset of 45.5(±13.3 Standard deviation SD) years and prolonged diagnostic delay (mean 59±75 SD months) was found. Six patients had an additional diagnosis of PD, 83% of depression and 66% of other functional neurological disorder. In four patients with FP+PD, FP preceded PD by 6 to 56months.
These results suggest that FP should be considered in the differential diagnosis of patients presenting with parkinsonism. The high rate of co-occurrence with PD emphasizes the importance of long-term follow up of these patients. The observation that FP often precedes PD should be verified in prospective studies.
Keywords
Adult, Age of Onset, Aged, Cross-Sectional Studies, Delayed Diagnosis, Female, Humans, Longitudinal Studies, Male, Middle Aged, Movement Disorders/classification, Movement Disorders/epidemiology, Parkinsonian Disorders/diagnosis, Parkinsonian Disorders/epidemiology, Parkinsonian Disorders/psychology, Prevalence, Switzerland/epidemiology, Functional movement disorder, Parkinsonism, Prodromal manifestation
Pubmed
Web of science
Create date
29/03/2018 19:02
Last modification date
20/08/2019 14:45
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