New approaches in metastatic melanoma: biological and molecular targeted therapies

Details

Serval ID
serval:BIB_863EEE4CB3D9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New approaches in metastatic melanoma: biological and molecular targeted therapies
Journal
Expert Review of Anticancer Therapy
Author(s)
Lejeune  F. J., Rimoldi  D., Speiser  D.
ISSN
1473-7140 (Print)
Publication state
Published
Issued date
05/2007
Volume
7
Number
5
Pages
701-13
Notes
Journal Article
Review --- Old month value: May
Abstract
Classical metastatic melanoma therapy is disappointing but important progress has been made in the understanding of melanoma biology. Genetic lesions and several intracellular signaling pathways that could serve as targets for novel therapy have been identified and a number of new agents are under evaluation. Promising tumor cell targets were identified in the cell membrane, cytoplasm and nucleus. New therapeutic approaches, besides monoclonal antibodies and vaccination, include an increasing number of small molecules that have been shown to interfere restrictively with intracellular signaling pathways in melanoma and decrease proliferation, survival, migration or invasion. Other agents can interfere with stromal components of melanoma, such as angiogenesis and components of the immune system.
Keywords
Angiogenesis Inhibitors/*therapeutic use Antineoplastic Agents/*therapeutic use Cancer Vaccines/therapeutic use Gene Therapy Humans *Immunotherapy Melanoma/blood supply/secondary/*therapy Receptor Protein-Tyrosine Kinases/antagonists & inhibitors Signal Transduction/*drug effects Skin Neoplasms/pathology Tumor Necrosis Factor-alpha/therapeutic use
Pubmed
Web of science
Create date
28/01/2008 11:33
Last modification date
20/08/2019 14:45
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