Interaction between widening of diameter of abdominal aorta and cardiovascular risk factors and atherosclerosis burden.

Details

Serval ID
serval:BIB_862CAB2A99E9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interaction between widening of diameter of abdominal aorta and cardiovascular risk factors and atherosclerosis burden.
Journal
Internal and Emergency Medicine
Author(s)
Glauser F., Mazzolai L., Darioli R., Depairon M.
ISSN
1970-9366 (Electronic)
ISSN-L
1828-0447
Publication state
Published
Issued date
2014
Volume
9
Number
4
Pages
411-417
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The aim of this study was to investigate influence of traditional cardiovascular risk factors (CVRF) and subclinical atherosclerosis (ATS) burden on early stages of abdominal aortic diameter (AAD) widening among adults. 2,052 consecutive patients (P) (39 % women), mean age 52 ± 13 years, were prospectively screened for CVRF, ATS, and AAD. B-mode ultrasound was used to evaluate the largest AAD and to detect carotid and femoral atherosclerotic plaques. Mean AAD was 15.2 ± 2.8 mm. Atherosclerotic plaques were detected in 71 % of patients. Significant univariate correlation between AAD, traditional CVRF, and ABS was found. However, multiple regression analysis showed that only seven of them were significantly and weakly correlated with AAD (R² = 0.27, p < 0.001). On the other hand, a multivariate logistic analysis was used to evaluate CVRF impact on enlarged AAD ≥25 mm (EAAD) as compared to those with AAD <25 mm. These factors did not account for more than 30 % of interaction (R² = 0.30, p = 0.001). Furthermore, despite a large proportion of patients with high number of CVRF, and subclinical ATS, rate of patients with AAD ≥25 mm was low (1 %) and scattered regardless their CHD risk score or ATS burden. In conclusion, these results suggest that although some traditional CVRF and presence of ATS are associated with early stages of EAAD, other determinants still need to be identified for a better understanding of abdominal aortic aneurysm pathogenesis.
Pubmed
Web of science
Create date
10/02/2014 11:09
Last modification date
20/08/2019 14:45
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