Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo (1)H MRS study of a hibernating mammal.

Details

Serval ID
serval:BIB_8621860548F0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo (1)H MRS study of a hibernating mammal.
Journal
Journal of Neurochemistry
Author(s)
Henry P.G., Russeth K.P., Tkac I., Drewes L.R., Andrews M.T., Gruetter R.
ISSN
0022-3042 (Print)
ISSN-L
0022-3042
Publication state
Published
Issued date
2007
Volume
101
Number
6
Pages
1505-1515
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Abstract
The brain of a hibernating mammal withstands physiological extremes that would result in cerebral damage and death in a non-hibernating species such as humans. To examine the possibility that this neuroprotection results from alterations in cerebral metabolism, we used in vivo(1)H NMR spectroscopy at high field (9.4 T) to measure the concentration of 18 metabolites (neurochemical profile) in the brain of 13-lined ground squirrels (Spermophilus tridecemlineatus) before, during, and after hibernation. Resolved in vivo(1)H NMR spectra were obtained even at low temperature in torpid hibernators ( approximately 7 degrees C). The phosphocreatine-to-creatine ratio was increased during torpor (+143%) indicating energy storage, and remained increased to a lesser extent during interbout arousal (IBA) (+83%). The total gamma-aminobutyric acid concentration was increased during torpor (+135%) and quickly returned to baseline during IBA. Glutamine (Gln) was decreased (-54%) during torpor but quickly returned to normal levels during IBA and after terminal arousal in the spring. Glutamate (Glu) was also decreased during torpor (-17%), but remained decreased during IBA (-20% compared with fall), and returned to normal level in the spring. Our observation that Glu and Gln levels are depressed in the brain of hibernators suggests that the balance between anaplerosis and loss of Glu and Gln (because of glutamatergic neurotransmission or other mechanisms) is altered in hibernation.
Keywords
Animals, Ascorbic Acid/metabolism, Aspartic Acid/analogs & derivatives, Aspartic Acid/metabolism, Brain/metabolism, Brain Chemistry, Choline/metabolism, Cold Temperature, Creatine/metabolism, Energy Metabolism/physiology, Ethanolamines/metabolism, Glucose/metabolism, Glutamic Acid/metabolism, Glutamine/metabolism, Glutathione/metabolism, Hibernation/physiology, Inositol/metabolism, Lactic Acid/metabolism, Magnetic Resonance Spectroscopy, Phosphocreatine/metabolism, Sciuridae/physiology, Synaptic Transmission/physiology, Taurine/metabolism, gamma-Aminobutyric Acid/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
04/08/2010 15:28
Last modification date
20/08/2019 14:45
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