Improved coronary artery definition with T2-weighted, free-breathing, three-dimensional coronary MRA.

Details

Serval ID
serval:BIB_8612CE063BDA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Improved coronary artery definition with T2-weighted, free-breathing, three-dimensional coronary MRA.
Journal
Circulation
Author(s)
Botnar R.M., Stuber M., Danias P.G., Kissinger K.V., Manning W.J.
ISSN
1524-4539[electronic], 0009-7322[linking]
Publication state
Published
Issued date
1999
Volume
99
Number
24
Pages
3139-3148
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Abstract
BACKGROUND: Three-dimensional (3D) navigator-gated and prospectively corrected free-breathing coronary magnetic resonance angiography (MRA) allows for submillimeter image resolution but suffers from poor contrast between coronary blood and myocardium. Data collected over >100 ms/heart beat are also susceptible to bulk cardiac and respiratory motion. To address these problems, we examined the effect of a T2 preparation prepulse (T2prep) for myocardial suppression and a shortened acquisition window on coronary definition. METHODS AND RESULTS: Eight healthy adult subjects and 5 patients with confirmed coronary artery disease (CAD) underwent free-breathing 3D MRA with and without T2prep and with 120- and 60-ms data-acquisition windows. The T2prep resulted in a 123% (P<0. 001) increase in contrast-to-noise ratio (CNR). Coronary edge definition was improved by 33% (P<0.001). Acquisition window shortening from 120 to 60 ms resulted in better vessel definition (11%; P<0.001). Among patients with CAD, there was a good correspondence with disease. CONCLUSIONS: Free-breathing, T2prep, 3D coronary MRA with a shorter acquisition window resulted in improved CNR and better coronary artery definition, allowing the assessment of coronary disease. This approach offers the potential for free-breathing, noninvasive assessment of the major coronary arteries.
Keywords
Adolescent, Adult, Aged, Artifacts, Contrast Media, Coronary Angiography/methods, Coronary Disease/diagnosis, Coronary Vessels, Female, Humans, Magnetic Resonance Angiography/methods, Male, Middle Aged, Respiration
Pubmed
Web of science
Create date
02/03/2010 16:04
Last modification date
20/08/2019 14:45
Usage data