The era of bioengineering: how will this affect the next generation of cancer immunotherapy?

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State: Public
Version: Final published version
Serval ID
serval:BIB_860F405AA782
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The era of bioengineering: how will this affect the next generation of cancer immunotherapy?
Journal
Journal of translational medicine
Author(s)
Graciotti M., Berti C., Klok H.A., Kandalaft L.
ISSN
1479-5876 (Electronic)
ISSN-L
1479-5876
Publication state
Published
Issued date
19/06/2017
Peer-reviewed
Oui
Volume
15
Number
1
Pages
142
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Immunotherapy consists of activating the patient's immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have emerged to harness the immune system against tumors, from the administration of immunomodulatory agents that activate immune cells, to therapeutic vaccines or infusion of previously activated cancer-specific T cells. However, despite great recent progress many difficulties still remain, which prevent the widespread use of immunotherapy. Some of these limitations include: systemic toxicity, weak immune cellular responses or persistence over time and most ultimately costly and time-consuming procedures.
Synthetic and natural biomaterials hold great potential to address these hurdles providing biocompatible systems capable of targeted local delivery, co-delivery, and controlled and/or sustained release. In this review we discuss some of the bioengineered solutions and approaches developed so far and how biomaterials can be further implemented to help and shape the future of cancer immunotherapy.
The bioengineering strategies here presented constitute a powerful toolkit to develop safe and successful novel cancer immunotherapies.

Keywords
Bioengineering, Cancer Vaccines/immunology, Humans, Immunologic Factors/therapeutic use, Immunotherapy, Neoplasms/drug therapy, Neoplasms/immunology, Neoplasms/therapy, Neoplastic Cells, Circulating/pathology
Pubmed
Web of science
Open Access
Yes
Create date
26/06/2017 8:11
Last modification date
20/08/2019 14:45
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