Vaccination and anaphylaxis: a forensic perspective.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_860BFA0753A6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vaccination and anaphylaxis: a forensic perspective.
Journal
Croatian medical journal
Author(s)
Palmiere C., Tettamanti C., Scarpelli M.P.
ISSN
1332-8166 (Electronic)
ISSN-L
0353-9504
Publication state
Published
Issued date
28/02/2017
Peer-reviewed
Oui
Volume
58
Number
1
Pages
14-25
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To review the available literature pertaining to fatalities following vaccine administration and, in particular, cases of vaccine-related fatal anaphylaxis.
The MEDLINE database was systematically searched up to March 2016 to identify all relevant articles pertaining to fatal cases of anaphylaxis following vaccine administration.
Six papers pertaining to fatal anaphylaxis following vaccination were found relevant. Mast cell tryptase and total IgE concentration was assessed exclusively in one case. Laryngeal edema was not detected in any of these cases, whereas eosinophil or mast cell infiltration was observed in lymphoid organs. In one case, immunohistochemical investigations using anti-tryptase antibodies allowed pulmonary mast cells and degranulating mast cells with tryptase-positive material outside to be identified.
In any suspected IgE-mediated fatal anaphylactic cases, biochemical investigations should be systematically performed for forensic purposes. Splenic tissue should be routinely sampled for immunohistochemical investigations in all suspected anaphylaxis-related deaths and mast cell/eosinophil infiltrations should be systematically sought out in the spleen, myocardium, and coronary artery wall. The hypothesis of fatal anaphylaxis following vaccination should be formulated exclusively when circumstantial data, available medical records, laboratory investigations, and autopsy or histology findings converge in a consistent pattern. The reasonable exclusion of alternative causes of death after all postmortem investigations is also imperative in order to establish or rule out a cause-and-effect relationship between vaccine administration and any presumptive temporarily-related death.

Pubmed
Web of science
Open Access
Yes
Create date
03/03/2017 15:47
Last modification date
20/08/2019 14:45
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