Relation between the resolution of HLA-typing and the chance of finding an unrelated bone marrow donor

Details

Serval ID
serval:BIB_86033B29408E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Relation between the resolution of HLA-typing and the chance of finding an unrelated bone marrow donor
Journal
Bone Marrow Transplantation
Author(s)
Speiser  D. E., Tiercy  J. M., Rufer  N., Chapuis  B., Morell  A., Kern  M., Gmur  J., Gratwohl  A., Roosnek  E., Jeannet  M.
ISSN
0268-3369 (Print)
Publication state
Published
Issued date
06/1994
Volume
13
Number
6
Pages
805-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
The chance of finding an unrelated bone marrow donor depends on the size of the donor registry, the frequency of the patient's HLA phenotype and the degree of histoincompatibility considered acceptable. We have studied 60 unrelated bone marrow donor searches and the probability of finding a donor when increasing HLA-compatibility requirements were applied. For 21 (35%) of the patients no donor could be identified who was (serologically) matched for all six ABDR antigens. For the remaining 39 (65%), a median of two (range 1-20) blood samples from serologically-matched potential donors was obtained for further analysis. Eighteen (30%) patients appeared to be mismatched with all the pre-selected donors because of DR (sub-)type mismatches detected by oligotyping. A further 7 (12%) patients did not have an MLC and/or cytotoxic T lymphocyte precursor (CTLp) negative donor. Thus, a 'perfectly matched' donor was found for 11 (18%) patients. To find a suitable donor for more patients we propose that many or all the potential donors identified in the various registries for a particular patient are simultaneously evaluated as many of the serologically ABDR-matched donors will appear to be incompatible after high resolution HLA-typing. This strategy will not only allow selection of the best matched donor more rapidly but the consequent use of high resolution typing might also lead to the definition of a certain number of acceptable mismatches.
Keywords
Bone Marrow Transplantation/*immunology HLA Antigens/*immunology *Histocompatibility Testing Humans Registries Tissue Donors
Pubmed
Web of science
Create date
28/01/2008 11:32
Last modification date
20/08/2019 14:45
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