Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report.

Details

Serval ID
serval:BIB_85FF7468C3C9
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report.
Journal
European heart journal. Case reports
Author(s)
Colombier S., Mahendiran T., Niclauss L., Kirsch M.
ISSN
2514-2119 (Electronic)
ISSN-L
2514-2119
Publication state
Published
Issued date
01/2021
Peer-reviewed
Oui
Volume
5
Number
1
Pages
ytaa475
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The new β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to exhibit cardiovascular pathogenicity through use of angiotensin-converting enzyme 2 (ACE2) for cell entry and the development of a major systemic inflammation. Furthermore, cardiovascular comorbidities increase susceptibility to SARS-CoV-2 infection and the development of a severe form of COronaVIrus Disease 2019 (COVID-19).
We describe the case of a COVID-19 patient whose inaugural presentation was a refractory cardiac arrest secondary to the destabilization of known, non-significant coronary artery disease. Patient was supported by venoarterial extracorporeal life support. After 12 h of support, cardiac function remained stable on low vasopressor support but the patient remained in a coma and brainstem death was diagnosed.
Myocardial injury is frequently seen among critically unwell COVID-19 patients and increases the risk of mortality. This case illustrates several potential mechanisms that are thought to drive the cardiac complications seen in COVID-19. We present the potential role of inflammation and ACE2 in the pathophysiology of COVID-19.
Keywords
COVID-19, Cardiac arrest, Case report, Extracorporeal life support, SARS-CoV-2
Pubmed
Web of science
Open Access
Yes
Create date
23/02/2021 8:07
Last modification date
22/05/2021 5:34
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