Effets d'une perfusion de facteur natriurétique auriculaire humain chez des volontaires sains [Effects of perfusion of human atrial natriuretic factor in normal volunteers]

Details

Serval ID
serval:BIB_85F811EAB016
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effets d'une perfusion de facteur natriurétique auriculaire humain chez des volontaires sains [Effects of perfusion of human atrial natriuretic factor in normal volunteers]
Journal
Schweizerische medizinische Wochenschrift
Author(s)
Bidiville J., Waeber G., Nussberger J., Biollaz J., Porchet M., Waeber B., Brunner H.R.
ISSN
0036-7672
Publication state
Published
Issued date
1986
Peer-reviewed
Oui
Volume
116
Number
49
Pages
1733-5
Language
french
Notes
Publication types: English Abstract ; Journal Article - Publication Status: ppublish
Abstract
The renal and systemic effects of a synthetic atrial natriuretic peptide (ANP) corresponding to the sequence of the human hormone was investigated in normal volunteers. Each subject was infused for 4 hours on 3 different days at a one week interval with either ANP (0.5 or 1 microgram/min) or its vehicle. ANP enhanced natriuresis without simultaneously modifying glomerular filtration rate. ANP did, however, reduce effective renal plasma flow. In spite of the increased natriuresis, the activity of the renin-angiotensin-aldosterone system was reduced during ANP infusion. ANP induced a transient increase in skin blood flow. No change in blood pressure and heart rate occurred in the course of the experiment.
Keywords
Adult, Atrial Natriuretic Factor, Blood Pressure, Glomerular Filtration Rate, Heart Rate, Humans, Male, Natriuresis, Perfusion, Renal Circulation, Renin-Angiotensin System, Skin
Pubmed
Web of science
Create date
25/01/2008 14:10
Last modification date
20/08/2019 14:45
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