Modeling the impact of lesions in the human brain.
Details
State: Public
Version: author
Serval ID
serval:BIB_85F6EAD9E383
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Modeling the impact of lesions in the human brain.
Journal
Plos Computational Biology
ISSN
1553-7358 (Electronic)
ISSN-L
1553-734X
Publication state
Published
Issued date
2009
Volume
5
Number
6
Pages
e1000408
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Lesions of anatomical brain networks result in functional disturbances of brain systems and behavior which depend sensitively, often unpredictably, on the lesion site. The availability of whole-brain maps of structural connections within the human cerebrum and our increased understanding of the physiology and large-scale dynamics of cortical networks allow us to investigate the functional consequences of focal brain lesions in a computational model. We simulate the dynamic effects of lesions placed in different regions of the cerebral cortex by recording changes in the pattern of endogenous ("resting-state") neural activity. We find that lesions produce specific patterns of altered functional connectivity among distant regions of cortex, often affecting both cortical hemispheres. The magnitude of these dynamic effects depends on the lesion location and is partly predicted by structural network properties of the lesion site. In the model, lesions along the cortical midline and in the vicinity of the temporo-parietal junction result in large and widely distributed changes in functional connectivity, while lesions of primary sensory or motor regions remain more localized. The model suggests that dynamic lesion effects can be predicted on the basis of specific network measures of structural brain networks and that these effects may be related to known behavioral and cognitive consequences of brain lesions.
Keywords
Algorithms, Brain Diseases/physiopathology, Brain Mapping, Cerebral Cortex/physiopathology, Computer Simulation, Humans, Models, Neurological, Nerve Net/physiopathology, Reproducibility of Results
Pubmed
Web of science
Open Access
Yes
Create date
29/06/2012 9:03
Last modification date
20/08/2019 15:45