Immunogenetics of Graves' ophthalmopathy

Details

Serval ID
serval:BIB_85684308E81A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunogenetics of Graves' ophthalmopathy
Journal
Clinical Endocrinology
Author(s)
Weetman  A. P., So  A. K., Warner  C. A., Foroni  L., Fells  P., Shine  B.
ISSN
0300-0664 (Print)
Publication state
Published
Issued date
06/1988
Volume
28
Number
6
Pages
619-28
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
We have performed an immunogenetic analysis of 53 patients with severe Graves' ophthalmopathy, 51 patients with Graves' disease but little or no clinically apparent eye disease, and 90 controls. The distribution of restriction fragment length polymorphisms was analysed in the three groups, using probes for the HLA-DQ alpha and DR beta regions, the T-cell receptor C alpha, V alpha, C beta and J gamma genes and the immunoglobulin gene switch regions, S alpha and S mu. There was no abnormal distribution of these polymorphisms in either group of Graves' patients, or differences between the Graves' patients with or without eye disease. It was possible to assign HLA-DR types in most patients using the polymorphisms found after probing with DQ alpha and DR beta; there was no abnormal distribution of DR types (including HLA-DR3) assigned by restriction fragment polymorphisms in the two Graves' groups. These results fail to confirm the reported associations between ophthalmopathy and HLA-DR3 and between Graves' disease and the T-cell receptor C beta polymorphism; they also argue against a strong influence of Gm allotypes in Graves' disease since these genes are in linkage disequilibrium with the S alpha polymorphisms. The association of Graves' disease with HLA-DR3, defined hitherto using serological reagents, may be less strong than previously described.
Keywords
Graves Disease/*genetics HLA-DQ Antigens/genetics HLA-DR Antigens/genetics Humans Immunoglobulin A/genetics Immunoglobulin M/genetics Polymorphism, Restriction Fragment Length Receptors, Antigen, T-Cell/genetics
Pubmed
Web of science
Create date
25/01/2008 9:39
Last modification date
20/08/2019 15:44
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