Mixed mucus-secreting and oncocytic carcinoma of the thyroid: pathologic, histochemical, immunohistochemical, and ultrastructural study of a case.

Details

Serval ID
serval:BIB_8519A13CDC75
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Mixed mucus-secreting and oncocytic carcinoma of the thyroid: pathologic, histochemical, immunohistochemical, and ultrastructural study of a case.
Journal
Archives of Pathology and Laboratory Medicine
Author(s)
Uccella S., La Rosa S., Finzi G., Erba S., Sessa F.
ISSN
0003-9985 (Print)
ISSN-L
0003-9985
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
124
Number
10
Pages
1547-1552
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
We report a carcinoma that is, to the best of our knowledge, the first case of a mixed mucus-secreting and oncocytic carcinoma of the thyroid. We also describe the histochemical, immunohistochemical, and ultrastructural features of this tumor. A 59-year-old man complaining of severe bone pain and weight loss underwent clinical and radiologic investigations. The studies revealed a nodule in the left thyroid lobe that was "cold" by (131)I scintiscan and multiple lytic lesions of the skeleton that showed increased uptake by (99m)Tc-Sestamibi scintiscan. Left hemithyroidectomy was performed and the surgical specimen contained a well-circumscribed nodule of 3 cm in the greatest diameter. Light microscopy showed an oncocytic carcinoma with an area of glandular and papillary proliferation of mucin-producing cells. A double histochemical approach (Alcian blue-periodic acid-Schiff and Alcian blue-high-iron diamine) combined with ultrastructural investigation confirmed the presence of true mucus, ruling out the presence of breakdown products of thyroglobulin. Ultrastructural and immunohistochemical studies, together with clinical findings, excluded a possible metastatic origin of the mucin-producing component.
Keywords
Adenocarcinoma, Mucinous/chemistry, Adenocarcinoma, Mucinous/pathology, Humans, Iodine Radioisotopes, Male, Microvilli/ultrastructure, Middle Aged, Mitochondria/ultrastructure, Mucus/chemistry, Secretory Vesicles/ultrastructure, Technetium Tc 99m Sestamibi, Thyroid Neoplasms/chemistry, Thyroid Neoplasms/pathology
Pubmed
Web of science
Create date
07/09/2016 8:30
Last modification date
20/08/2019 14:44
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