Recent developments in the use of isotope ratio mass spectrometry in sports drug testing.

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Serval ID
serval:BIB_84F8F6718F5F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Recent developments in the use of isotope ratio mass spectrometry in sports drug testing.
Journal
Analytical and Bioanalytical Chemistry
Author(s)
Piper T., Emery C., Saugy M.
ISSN
1618-2650 (Electronic)
Publication state
Published
Issued date
08/2011
Peer-reviewed
Oui
Volume
401
Number
2
Pages
433-447
Language
english
Abstract
According to the annual report of the World Anti-Doping Agency, steroids are the most frequently detected class of doping agents. Detecting the misuse of endogenously occurring steroids, i.e. steroids such as testosterone that are produced naturally by humans, is one of the most challenging issues in doping control analysis. The established thresholds for urinary concentrations or concentration ratios such as the testosterone/epitestosterone quotient are sometimes inconclusive owing to the large biological variation in these parameters.For more than 15 years, doping control laboratories focused on the carbon isotope ratios of endogenous steroids to distinguish between naturally elevated steroid profile parameters and illicit administration of steroids. A variety of different methods has been developed throughout the last decade and the number of different steroids under investigation by isotope ratio mass spectrometry has recently grown considerably. Besides norandrosterone, boldenone was found to occur endogenously in rare cases and the misuse of corticosteroids or epitestosterone can now be detected with the aid of carbon isotope ratios as well. In addition, steroids excreted as sulfoconjugates were investigated, and the first results regarding hydrogen isotope ratios recently became available.All of these will be presented in detail within this review together with some considerations on validation issues and on identification of parameters influencing steroidal isotope ratios in urine.
Keywords
Carbon Isotopes, Doping in Sports, Humans, Mass Spectrometry, Performance-Enhancing Substances/urine, Sensitivity and Specificity, Sports, Steroids/urine, Substance Abuse Detection/methods
Pubmed
Web of science
Open Access
Yes
Create date
06/01/2012 14:21
Last modification date
01/10/2019 6:18
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