Cognitive efficacy of quetiapine in early-onset first-episode psychosis: a 12-week open label trial.

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State: Public
Version: author
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Serval ID
serval:BIB_84812EC41BE8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cognitive efficacy of quetiapine in early-onset first-episode psychosis: a 12-week open label trial.
Journal
Psychiatric Quarterly
Author(s)
Urben Sébastien, Baumann Pierre, Barcellona Sandra, Hafil M., Preuss Ulrich, Peter-Favre Claire, Clarke Stéèphanie, Halfon Olivier, Holzer Laurent
ISSN
1573-6709 (Electronic)
ISSN-L
0033-2720
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
83
Number
3
Pages
311-324
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Abstract
Twenty-three adolescents with psychotic disorders, aged from 13 to 18 years, participated in a 12-week open label trial (17 adolescents completed the study) in order to examine the impact of quetiapine on clinical status and cognitive functions (encompassing processing speed, attention, short-term memory, long-term memory and executive function). An improvement in Clinical Global Impression and Positive and Negative Symptom Scale (P's ≤ 0.001) was observed. In addition, after controlling for amelioration of symptoms, a significant improvement was observed on one executive function (P = 0.044; Trail Making Part B). The remaining cognitive abilities showed stability. In addition, we observed an interaction between quetiapine doses (>300 mg/day or <300 mg/day) and time, where lower doses showed more improvement in verbal short-term memory (P = 0.048), inhibition abilities (P = 0.038) and positive symptoms (P = 0.020). The neuropsychological functioning of adolescents with psychotic disorders remained mainly stable after 12 weeks of treatment with quetiapine. However, lower doses seemed to have a better impact on two components of cognition (inhibition abilities and verbal short-term memory) and on positive symptoms.
Keywords
Adolescent, Adult, Analysis of Variance, Antipsychotic Agents/administration & dosage, Antipsychotic Agents/pharmacology, Cognition Disorders/drug therapy, Cognition Disorders/psychology, Dibenzothiazepines/administration & dosage, Dibenzothiazepines/pharmacology, Dose-Response Relationship, Drug, Female, Humans, Male, Neuropsychological Tests/statistics & numerical data, Nootropic Agents/administration & dosage, Nootropic Agents/pharmacology, Psychiatric Status Rating Scales/statistics & numerical data, Psychotic Disorders/drug therapy, Psychotic Disorders/psychology, Schizophrenia/drug therapy, Schizophrenic Psychology, Severity of Illness Index, Treatment Outcome
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Web of science
Create date
28/11/2011 16:44
Last modification date
01/02/2021 6:24
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