Effect of lipid oxidation on the regulation of glucose utilization in obese patients

Details

Serval ID
serval:BIB_847F7362B590
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effect of lipid oxidation on the regulation of glucose utilization in obese patients
Journal
Acta Diabetologica
Author(s)
Golay  A., Felber  J. P., Jallut  D., Munger  R., Ruiz  J., Jequier  E.
ISSN
0940-5429
Publication state
Published
Issued date
03/1995
Volume
32
Number
1
Pages
44-8
Notes
95337409
0940-5429
Journal Article --- Old month value: Mar --- Old uritopublisher value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7612917
Abstract
The effect of changes in lipid oxidation on glucose utilization (storage and oxidation) was studied in seven nondiabetic obese patients. They participated in three protocols in which: (1) Intralipid (to raise plasma FFA concentrations), (2) beta-pyridylcarbinol [a precursor of nicotinic acid, to lower plasma free fatty acids (FFA) concentrations], or (3) isotonic saline were infused over 2 h. Thereafter, these infusions were discontinued, and a 2-h euglycemic, hyperinsulinemic clamp was performed to measure glucose uptake. All studies were carried out in combination with indirect calorimetry to measure oxidative and nonoxidative glucose disposal (glucose storage). The high plasma FFA concentrations (1024 +/- 57 mumol/l) and lipid oxidation rates (1.1 +/- 0.1 mg/kg.min) found at the end of the Intralipid infusion and the low plasma FFA concentrations (264 +/- 26 mumol/l) and lipid oxidation rates (0.7 +/- 0.1 mg/kg.min) found at the end of the beta-pyridylcarbinol infusions resulted in significantly different rates of total and nonoxidative glucose disposal during the insulin clamp. The values were 2.6 +/- 0.6 mg/kg.min after Intralipid and 4.1 +/- 1.0 mg/kg.min after beta-pyridylcarbinol for total glucose disposal, and 0.4 +/- 0.4 and 1.6 +/- 0.8, respectively for nonoxidative glucose disposal. In conclusion, these observations show that changes in lipid oxidation rates preceding a glucose load influence glucose disposal and glycogen storage in obese subjects.
Keywords
Adult Blood Glucose/*metabolism Calorimetry Fat Emulsions, Intravenous Fatty Acids, Nonesterified/*blood Female Glucose/*metabolism Glucose Clamp Technique Human Infusions, Intravenous Insulin/administration & dosage/*pharmacology Male Middle Age Obesity/blood/*metabolism Oxidation-Reduction
Pubmed
Web of science
Create date
03/03/2008 15:16
Last modification date
20/08/2019 14:44
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