Regulation of lytic and non-lytic functions of gasdermin pores.

Details

Serval ID
serval:BIB_84772DDF6481
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Regulation of lytic and non-lytic functions of gasdermin pores.
Journal
Journal of molecular biology
Author(s)
Rühl S., Broz P.
ISSN
1089-8638 (Electronic)
ISSN-L
0022-2836
Publication state
In Press
Peer-reviewed
Oui
Pages
167246
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Pyroptosis is a necrotic form of cell death that was initially found to be induced upon activation of inflammatory caspases by inflammasome complexes. Mechanistically, pyroptosis induction requires cleavage of the caspase substrate gasdermin D (GSDMD), and the release of the GSDMD N-terminal fragment, which targets the plasma membrane to form large β-barrel pores. GSDMD shares this pore-forming ability with other gasdermin family members, which induce pyroptosis during infection or upon treatment with chemotherapy drugs. While induction of cell death has been assumed to be the main function of the gasdermin pores, increasing evidence suggests that these pores have non-lytic functions, such as in releasing cytokines, alarmins and regulating intracellular signaling via ionic fluxes. Here we discuss how gasdermin pore formation is regulated to induce membrane permeabilization or lysis, how gasdermin pores achieve specificity for cargo-release and how cells repair gasdermin-induced damage in the plasma membrane.
Keywords
pyroptosis Gasdermins Inflammasomes Cell death ESCRT
Pubmed
Open Access
Yes
Create date
27/09/2021 10:44
Last modification date
01/10/2021 5:40
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