PurposeTo present a case of non-uveal intraocular metastatic disease originating from relapsed breast carcinoma.MethodsWe report a 67-year-old female with a history of HER2-positive breast carcinoma in remission and recent squamous cell carcinoma of the esophagus presenting with ocular symptoms. Comprehensive ophthalmic examinations and multimodal imaging were performed. Diagnostic procedures included diagnostic vitrectomy and cytology analysis.ResultsThe patient was found to have metastatic carcinoma to the vitreous and retina with an immunophenotype compatible with breast carcinoma. Neurological symptoms led to the discovery of metastatic brain lesions. The patient underwent palliative systemic treatment and stereotactic brain irradiation. Follow-up showed the progression of the ocular lesions.ConclusionThis case informs on the clinical and pathological findings of a rare non-uveal intraocular metastatic disease originating from relapsed breast carcinoma. Vitreous biopsy and multimodal imaging were required for a proper diagnosis and management and would serve as a reference for further cases.