Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung's disease

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Serval ID
serval:BIB_83FC69A8ADAD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung's disease
Journal
Pediatric Surgery International
Author(s)
Newman  C. J., Laurini  R. N., Lesbros  Y., Reinberg  O., Meyrat  B. J.
ISSN
0179-0358 (Print)
Publication state
Published
Issued date
11/2003
Volume
19
Number
9-10
Pages
662-8
Notes
Journal Article --- Old month value: Nov
Abstract
Surgery for Hirschsprung's disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease with that in normal colon. We correlated these results with the corresponding neural intestinal histology determined by CD56 and the protein gene product 9.5 immunohistochemistry. The distribution of ICC in the proximal segment of resected bowel is identical to that of normal colon, regardless of normal or abnormal colon innervation. ICC distribution does not seem to contribute to post-operative bowel motility disorders in patients operated for Hirschsprung's disease
Keywords
Child Child, Preschool Enteric Nervous System/*cytology/pathology/physiopathology Female Hirschsprung Disease/pathology/*physiopathology Humans Infant Intestine, Large/*cytology/*innervation/pathology Male Retrospective Studies
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 10:09
Last modification date
01/10/2019 7:18
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