Serum calcium levels are associated with novel cardiometabolic risk factors in the population-based CoLaus study.

Details

Ressource 1Download: BIB_83EF35EBAE22.P001.pdf (477.51 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_83EF35EBAE22
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Serum calcium levels are associated with novel cardiometabolic risk factors in the population-based CoLaus study.
Journal
PLoS One
Author(s)
Guessous I., Bonny O., Paccaud F., Mooser V., Waeber G., Vollenweider P., Bochud M.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
6
Number
4
Pages
e18865
Language
english
Abstract
BACKGROUND: Associations of serum calcium levels with the metabolic syndrome and other novel cardio-metabolic risk factors not classically included in the metabolic syndrome, such as those involved in oxidative stress, are largely unexplored. We analyzed the association of albumin-corrected serum calcium levels with conventional and non-conventional cardio-metabolic risk factors in a general adult population.
METHODOLOGY/PRINCIPAL FINDINGS: The CoLaus study is a population-based study including Caucasians from Lausanne, Switzerland. The metabolic syndrome was defined using the Adult Treatment Panel III criteria. Non-conventional cardio-metabolic risk factors considered included: fat mass, leptin, LDL particle size, apolipoprotein B, fasting insulin, adiponectin, ultrasensitive CRP, serum uric acid, homocysteine, and gamma-glutamyltransferase. We used adjusted standardized multivariable regression to compare the association of each cardio-metabolic risk factor with albumin-corrected serum calcium. We assessed associations of albumin-corrected serum calcium with the cumulative number of non-conventional cardio-metabolic risk factors. We analyzed 4,231 subjects aged 35 to 75 years. Corrected serum calcium increased with both the number of the metabolic syndrome components and the number of non-conventional cardio-metabolic risk factors, independently of the metabolic syndrome and BMI. Among conventional and non-conventional cardio-metabolic risk factors, the strongest positive associations were found for factors related to oxidative stress (uric acid, homocysteine and gamma-glutamyltransferase). Adiponectin had the strongest negative association with corrected serum calcium.
CONCLUSIONS/SIGNIFICANCE: Serum calcium was associated with the metabolic syndrome and with non-conventional cardio-metabolic risk factors independently of the metabolic syndrome. Associations with uric acid, homocysteine and gamma-glutamyltransferase were the strongest. These novel findings suggest that serum calcium levels may be associated with cardiovascular risk via oxidative stress.
Keywords
Adult, Body Mass Index, Calcium/blood, Cardiovascular Diseases/blood, Cardiovascular Diseases/epidemiology, Female, Humans, Male, Metabolic Diseases/blood, Metabolic Diseases/epidemiology, Middle Aged, Risk Factors, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
04/05/2011 10:40
Last modification date
20/08/2019 15:43
Usage data