Clinical outcome after a reactive hypothermic EEG following cardiac arrest.

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Serval ID
serval:BIB_83EADF2AE2A2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical outcome after a reactive hypothermic EEG following cardiac arrest.
Journal
Neurocritical Care
Author(s)
Tsetsou S., Oddo M., Rossetti A.O.
ISSN
1556-0961 (Electronic)
ISSN-L
1541-6933
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
19
Number
3
Pages
283-286
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish. PDF type: original research
Abstract
BACKGROUND: Reactive electroencephalography (EEG) background during therapeutic hypothermia (TH) is related to favorable prognosis after cardiac arrest (CA), but its predictive value is not 100 %. The aim of this study was to investigate outcome predictors after a first reactive EEG recorded during TH after CA.
METHODS: We studied a cohort of consecutive comatose adults admitted between February 2008 and November 2012, after successful resuscitation from CA, selecting patients with reactive EEG during TH. Outcome was assessed at three months, and categorized as survivors and non-survivors (no patient was in vegetative state). Demographics, clinical variables, EEG features, serum neuron-specific enolase (NSE) and procalcitonin, were compared using uni- and multivariable analyses.
RESULTS: A total of 290 patients were treated with TH after cardiac arrest; 146 had an EEG during TH, which proved reactive in 90 of them; 77 (86 %) survived and 13 (14 %) died (without recovery from coma). The group of non-survivors had a higher occurrence of discontinuous EEG (p = 0.006; multivariate analysis p = 0.026), and a higher serum NSE peak (p = 0.021; multivariate analysis p = 0.014); conversely, demographics, and other clinical variables including serum procalcitonin did not differ.
CONCLUSIONS: A discontinuous EEG and high serum NSE are associated with mortality after CA in patients with poor outcome despite a reactive hypothermic EEG. This suggests more severe cerebral damage, but not to higher extent of systemic disease.
Pubmed
Web of science
Open Access
Yes
Create date
25/11/2013 9:17
Last modification date
01/10/2019 7:18
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