The appearance of joint manifestations in the Swiss inflammatory bowel disease cohort.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_83EA53E927F9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The appearance of joint manifestations in the Swiss inflammatory bowel disease cohort.
Journal
PloS one
Author(s)
Hiller A., Biedermann L., Fournier N., Butter M., Vavricka S.R., Ciurea A., Rogler G., Scharl M.
Working group(s)
Swiss IBD Cohort Study Group
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
14
Number
4
Pages
e0211554
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Extraintestinal manifestations (EIM) involving joints, skin, eyes and liver represent an important problem in the treatment of IBD patients. The aim of this study was to identify factors that are associated with the occurrence of joint EIM and therefore allow an early diagnosis and guide medical treatment.
We studied clinical and epidemiological data from 3298 patients included in the Swiss IBD Cohort Study (SIBDCS), 1860 suffered from Crohn's disease (CD) and 1438 from ulcerative colitis or IBD unclassified (UC/IBDU).
We found female gender as well as a longer disease duration and activity (specified as CDAI or MTWAI, respectively) to be related to the appearance of arthritis/arthralgia, but also sacroiliitis/ankylosing spondylitis in IBD patients. IBD patients with arthritis/arthralgia or sacroiliitis/ankylosing spondylitis were more often treated with anti-TNF and patients with arthritis/arthralgia underwent more often IBD-related surgeries. We revealed that eye or skin EIM were more frequent in patients with arthritis/arthralgia or sacroiliitis/ankylosing spondylitis. In multivariate analysis, we confirmed female gender, longer disease duration, IBD-related surgery, presence of other EIM and treatment with anti-TNF to be independent risk factors for the onset of arthritis/arthralgia in CD and UC/IBDU patients.
In this study, we demonstrated that markers for a more severe disease course were associated with the onset of joint EIM in IBD patients. Our data suggest that in particular females under anti-TNF treatment and patients suffering from non-joint and/or IBD-related surgery should be close and carefully monitored for presence of arthritis or sacroiliitis/ankylosing spondylitis.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Arthritis/etiology, Cohort Studies, Colitis, Ulcerative/complications, Colitis, Ulcerative/drug therapy, Crohn Disease/complications, Crohn Disease/drug therapy, Female, Humans, Male, Middle Aged, Risk Factors, Sex Factors, Spondylitis, Ankylosing/etiology, Switzerland/epidemiology, Tumor Necrosis Factor-alpha/antagonists & inhibitors, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
06/05/2019 17:13
Last modification date
04/01/2020 7:17
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