Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance.

Details

Serval ID
serval:BIB_83B6300AE872
Type
Article: article from journal or magazin.
Collection
Publications
Title
Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance.
Journal
Transplantation Proceedings
Author(s)
Boyman O., Krieg C., Letourneau S., Webster K., Surh C.D., Sprent J.
ISSN
1873-2623 (Electronic)
ISSN-L
0041-1345
Publication state
Published
Issued date
2012
Volume
44
Number
4
Pages
1032-1034
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The biological activity of interleukin (IL)-2 and other cytokines in vivo can be augmented by binding to certain anti-cytokine monoclonal antibodies (mAb). Here, we review evidence on how IL-2/anti-IL-2 mAb complexes can be used to cause selective stimulation and expansion of certain T-cell subsets. With some anti-IL-2 mAbs, injection of IL-2/mAb complexes leads to expansion of CD8 T effector cells but not CD4 T regulatory cells (Tregs); these complexes exert less adverse side effects than soluble IL-2 and display powerful antitumor activity. Other IL-2/mAb complexes have minimal effects on CD8 T cells but cause marked expansion of Tregs. Preconditioning mice with these complexes leads to permanent acceptance of MHC-disparate pancreatic islets in the absence of immunosuppression.
Pubmed
Web of science
Create date
14/06/2012 18:28
Last modification date
03/03/2018 18:53
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