Hepatitis C virus dynamics among intravenous drug users suggest that an annual treatment uptake above 10% would eliminate the disease by 2030.

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State: Serval
Version: author
Serval ID
serval:BIB_83B0D106C567
Type
Article: article from journal or magazin.
Collection
Publications
Title
Hepatitis C virus dynamics among intravenous drug users suggest that an annual treatment uptake above 10% would eliminate the disease by 2030.
Journal
Swiss medical weekly
Author(s)
Bruggmann P., Blach S., Deltenre P., Fehr J., Kouyos R., Lavanchy D., Müllhaupt B., Rauch A., Razavi H., Schmid P., Semela D., Stoeckle M., Negro F.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
147
Pages
w14543
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In Switzerland, the prevalence of hepatitis C virus (HCV) among people who inject drugs (PWID) has been decreasing owing to active harm reduction efforts and an aging population. Recent advances in HCV therapeutics may provide an opportunity to direct treatment to high-risk populations, with a goal of reducing HCV prevalence and preventing new infections. In order to guide these efforts, the current project was undertaken with the following aims: (1) to develop a simple model to estimate the number of new HCV infections using available data on PWID; (2) to examine the impact of intervention strategies (prevention and treatment) on new and total HCV infections among PWID.
A dynamic HCV transmission model was used to track HCV incidence and prevalence among active PWID according to their harm reduction status. The relative impact of treating 1, 5, 10 or 15% of HCV+ PWID with new oral direct acting antivirals was considered.
In 2015, there were an estimated 10 160 active PWID in Switzerland, more than 85% of whom were engaged in harm reduction programmes. Approximately 42% of active PWID were HCV-RNA+, with 55 new viraemic infections occurring annually. By 2030, a 60% reduction in the HCV+ PWID population would be expected. In the absence of behavioural changes, the number of secondary infections would increase under all treatment scenarios. With high level treatment, the number of secondary infections would peak and then drop, corresponding to depletion of the viral pool. In Switzerland, 5% treatment of the 2015 HCV+ PWID population per year would result in a 95% reduction in total cases by 2030, whereas ≥10% treatment would result in a >99% reduction.
Timely treatment of hepatitis C virus among people who inject drugs is necessary to reduce the prevalence and prevent new infections in Switzerland.
Keywords
Antiviral Agents/therapeutic use, Drug Users/statistics & numerical data, Harm Reduction, Hepacivirus/drug effects, Hepatitis C, Chronic/drug therapy, Hepatitis C, Chronic/epidemiology, Hepatitis C, Chronic/transmission, Humans, Incidence, Models, Statistical, Prevalence, Substance Abuse, Intravenous/epidemiology, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
22/11/2017 11:55
Last modification date
08/05/2019 21:17
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