Complément et rein [Complement system and kidney]

Details

Serval ID
serval:BIB_83627E067A3D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Complément et rein [Complement system and kidney]
Journal
Revue medicale suisse
Author(s)
Halfon M., Pascual M., Sadallah S., Fakhouri F.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
24/02/2021
Peer-reviewed
Oui
Volume
17
Number
727
Pages
383-388
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In the last few years, there has been a growing interest in the study of complement, fueleld mainly by the design of complement modulators, especially the C5-blocker eculizumab. The latter has significantly improved the prognosis of some nephropathies, such as the atypical hemolytic uremic syndrome. This breakthrough is a perfect example of fundamental translational research leading to clinical applications for patients. Currently, new molecules are being developed and some of them have already demonstrated clinical efficacy, such as avacopan (C5aR blocker) in ANCA vasculitis. As for kidney transplantation, complement modulators may lead to a new perspective in the treatment of some complications, such as humoral rejection. However, complement modulators carry the side effects, especially the infectious, and high costs.
Keywords
Drug-Related Side Effects and Adverse Reactions, Humans, Kidney, Kidney Transplantation, Vasculitis
Pubmed
Create date
09/03/2021 15:49
Last modification date
07/07/2021 6:36
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