Blood pressure response to antihypertensive therapy: ambulatory versus office blood pressure readings

Details

Serval ID
serval:BIB_835F5B4045D1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blood pressure response to antihypertensive therapy: ambulatory versus office blood pressure readings
Journal
Journal of Hypertension
Author(s)
Rion  F., Waeber  B., Graf  H. J., Jaussi  A., Porchet  M., Brunner  H. R.
ISSN
0263-6352 (Print)
Publication state
Published
Issued date
04/1985
Volume
3
Number
2
Pages
139-43
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
Blood pressure readings obtained by the physician in his office and ambulatory blood pressures recorded with the semi-automatic Remler device, were compared during a controlled antihypertensive drug trial. Either timolol or methyldopa was administered in in double-blind fashion to 30 patients with uncomplicated essential hypertension. All exhibited a diastolic office blood pressure greater than 95 mmHg at the end of a four-week placebo period. All patients then received a combination of hydrochlorothiazide (25 mg/day) and amiloride (2.5 mg/day). After four weeks of diuretic therapy, timolol (10 mg/day, n = 14) or methyldopa (250 mg/day, n = 16) were added randomly for six weeks. The dose of all antihypertensive agents was doubled after two weeks of therapy with diuretics combined with timolol (n = 7) or methyldopa (n = 16) because of the persistence of diastolic blood pressure levels greater than 90 mmHg at the office. When assessed in the office, the antihypertensive effect of timolol and methyldopa was similar. During ambulatory blood pressure monitoring, however, pressure levels were lower in the patients given timolol (P less than 0.05 for the diastolic). With both regimens, the blood pressure response measured outside the clinic during usual daily activities could not be predicted from that observed with office blood pressure readings. Furthermore the magnitude of the drug induced blood pressure decrease was more reproducible in time when determined outside the clinic. These data suggest that ambulatory blood pressure monitoring is more precise in evaluating the efficacy of antihypertensive therapy than office blood pressure measurement.
Keywords
Activities of Daily Living Adult Aged Antihypertensive Agents/therapeutic use Blood Pressure/*drug effects Blood Pressure Determination/instrumentation Double-Blind Method Drug Evaluation Female Humans Hypertension/*drug therapy Male Methyldopa/*therapeutic use Middle Aged Office Visits Timolol/*therapeutic use
Pubmed
Web of science
Create date
28/01/2008 12:54
Last modification date
20/08/2019 15:43
Usage data