The contractile properties of vaginal myofibroblasts: is the myofibroblasts contraction force test a valuable indication of future prolapse development?

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State: Public
Version: Final published version
Serval ID
serval:BIB_82F1764A6CEC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The contractile properties of vaginal myofibroblasts: is the myofibroblasts contraction force test a valuable indication of future prolapse development?
Journal
International Urogynecology Journal and Pelvic Floor Dysfunction
Author(s)
Meyer S., Achtari C., Hohlfeld P., Juillerat-Jeanneret L.
ISSN
0937-3462
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
19
Number
10
Pages
1399-1403
Language
english
Abstract
Using a specific myofibroblast contraction test, we try to predict future utero-vaginal prolapse development in young primiparae women. We compare myofibroblast cultures of the vaginal wall in primiparae women (group 1), young multiparae women (group 2) and older multiparae women (group 3) who were operated on for severe utero-vaginal prolapse. A myofibroblast-mediated collagen gel contraction assay determined a contraction factor that was compared in the three groups of women. The myofibroblasts contraction factor after 24 and 48 hours was significantly higher in group 1 women (2.4 +/- 0.6/4.4 +/- 1.9) compared to group 2 (1.6 +/- 0.3/ 1.8 +/- 0.1) andgroup 3 (1.6 +/- 0.3/1.8 +/- 0.3), but showed no differences in group 1 women without (2.1 +/- 0.5/3.5 +/- 1.9) and with (2.7 +/- 0.6/5.1 +/- 1.7) cystocoele. Vaginal myofibroblasts of young women show better contraction forces than young women with severe utero-vaginal prolapse. The latter have a myofibroblast contraction factor similar to those of older post-menopausal women operated for the same condition.
Keywords
Adult, Disease Progression, Female, Fibroblasts, Follow-Up Studies, Humans, Middle Aged, Muscle Contraction, Myofibrils, Prognosis, Uterine Prolapse, Vagina
Pubmed
Web of science
Create date
06/06/2008 10:58
Last modification date
20/08/2019 15:42
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