Regulation of innate and adaptive immunity by Notch.

Details

Serval ID
serval:BIB_82E4057B40F5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Regulation of innate and adaptive immunity by Notch.
Journal
Nature Reviews. Immunology
Author(s)
Radtke F., Macdonald H.R., Tacchini-Cottier F.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Publication state
Published
Issued date
2013
Volume
13
Number
6
Pages
427-437
Language
english
Abstract
Coordinated function of the innate and adaptive arms of the immune system in vertebrates is essential to promote protective immunity and to avoid immunopathology. The Notch signalling pathway, which was originally identified as a pleiotropic mediator of cell fate in invertebrates, has recently emerged as an important regulator of immune cell development and function. Notch was initially shown to be a key determinant of cell-lineage commitment in developing lymphocytes, but it is now known to control the homeostasis of several innate cell populations. Moreover, the roles of Notch in adaptive immunity have expanded to include the regulation of T cell differentiation and function. The aim of this Review is to summarize the current status of immune regulation by Notch. A better understanding of Notch function in both innate and adaptive immunity will hopefully provide multiple avenues for therapeutic intervention in disease.
Pubmed
Web of science
Create date
01/07/2013 8:08
Last modification date
20/08/2019 14:42
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