Intrinsic connectivity of human superior colliculus.

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Serval ID
serval:BIB_82ACC3EC45E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intrinsic connectivity of human superior colliculus.
Journal
Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation cérébrale
Author(s)
Tardif E., Delacuisine B., Probst A., Clarke S.
ISSN
0014-4819
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
166
Number
3-4
Pages
316-324
Language
english
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Oct
Abstract
The superior colliculus (SC) is believed to play an important role in sensorimotor integration and orienting behavior. It is classically divided into superficial layers predominantly containing visual neurons and deep layers containing multisensory and premotor neurons. Investigations of intrinsic connectivity within the SC in non-human species initially led to controversy regarding the existence of interlaminar connections between superficial and deep layers. It now seems more likely that such connections exist in a number of species, including non-human primates. In the latter, anatomical data concerning intrinsic SC connectivity are restricted to a limited number of intracellularly labeled neurons. No studies have been conducted to investigate the existence of intrinsic connections of human SC. In the present study, DiI (1,1'-dioctadecyl-3,3,3',3'- tetramethylindocarbocyanine perchlorate) and BDA (biotinylated dextran amine) were two tracers used in post-mortem human brains to examine intrinsic SC connections. Injections into the superficial layers revealed tangential connections within superficial layers and radial superficial-layer to deep-layer connections. Within superficial layers, horizontal connections were found over the entire rostro-caudal axis and were mostly directed laterally, i.e. toward the brachium of the inferior colliculus. Superficial-layer to deep-layer connections were more prominent in sections containing the injection site or located close to it. In these sections, an axon bundle having roughly the same diameter as the injection site crossed all deep layers, and individual axons displayed en passant or terminal boutons. The present results suggest that intrinsic connections within superficial layers and radial superficial-layers to deep-layers exist in human SC. The putative roles of these connections are discussed with regard to visual receptive field organization, as well as visuomotor and multisensory integration.
Keywords
Aged, Aged, 80 and over, Axons, Biotin, Carbocyanines, Dextrans, Female, Fluorescent Dyes, Functional Laterality, Histocytochemistry, Humans, Male, Microscopy, Confocal, Neural Pathways, Superior Colliculi
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:34
Last modification date
01/10/2019 6:18
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