Les anti-TNF-α pour le traitement des uvéites non infectieuses [Anti-TNF-α in the treatment of non-infectious uveitis]

Details

Serval ID
serval:BIB_82A64D30F890
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Les anti-TNF-α pour le traitement des uvéites non infectieuses [Anti-TNF-α in the treatment of non-infectious uveitis]
Journal
Medecine sciences
Author(s)
Hoogewoud F., Kowalczuk L., Bousquet E., Brézin A., Touchard E., Buggage R., Bordet T., Behar-Cohen F.
ISSN
1958-5381 (Electronic)
ISSN-L
0767-0974
Publication state
Published
Issued date
10/2020
Peer-reviewed
Oui
Volume
36
Number
10
Pages
893-899
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
Non-infectious uveitis is a heterogenous group of potentially blinding ocular autoimmune diseases that may represent a manifestation of a systemic condition or may affect the eyes only. A systemically administered anti-TNF has recently been approved for the treatment of non-infectious uveitis, broadening the therapeutic arsenal available to control intraocular inflammation and reduce uveitis complications that can lead to vision loss. When uveitis affects only the eyes, a local anti-TNF-α administration strategy could optimize the ocular therapeutic effect and reduce undesirable systemic side-effects. A new ocular method of non-viral gene therapy, currently in development, may broaden the indications for ocular anti-TNF-α agents, not only for uveitis but also for other diseases in which TNF-α-mediated neuro-inflammation has been demonstrated.
Pubmed
Open Access
Yes
Create date
09/10/2020 12:13
Last modification date
16/02/2021 7:26
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