Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice.

Details

Serval ID
serval:BIB_81E06F819425
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Hubbard J., Kobayashi Frisk M., Ruppert E., Tsai J.W., Fuchs F., Robin-Choteau L., Husse J., Calvel L., Eichele G., Franken P., Bourgin P.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
22/06/2021
Peer-reviewed
Oui
Volume
118
Number
25
Pages
e2017364118
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Artificial lighting, day-length changes, shift work, and transmeridian travel all lead to sleep-wake disturbances. The nychthemeral sleep-wake cycle (SWc) is known to be controlled by output from the central circadian clock in the suprachiasmatic nuclei (SCN), which is entrained to the light-dark cycle. Additionally, via intrinsically photosensitive retinal ganglion cells containing the photopigment melanopsin (Opn4), short-term light-dark alternations exert direct and acute influences on sleep and waking. However, the extent to which longer exposures typically experienced across the 24-h day exert such an effect has never been clarified or quantified, as disentangling sustained direct light effects (SDLE) from circadian effects is difficult. Recording sleep in mice lacking a circadian pacemaker, either through transgenesis (Syt10 <sup>cre/cre</sup> Bmal1 <sup>fl/-</sup> ) or SCN lesioning and/or melanopsin-based phototransduction (Opn4 <sup>-/-</sup> ), we uncovered, contrary to prevailing assumptions, that the contribution of SDLE is as important as circadian-driven input in determining SWc amplitude. Specifically, SDLE were primarily mediated (>80%) through melanopsin, of which half were then relayed through the SCN, revealing an ancillary purpose for this structure, independent of its clock function in organizing SWc. Based on these findings, we designed a model to estimate the effect of atypical light-dark cycles on SWc. This model predicted SWc amplitude in mice exposed to simulated transequatorial or transmeridian paradigms. Taken together, we demonstrate this SDLE is a crucial mechanism influencing behavior on par with the circadian system. In a broader context, these findings mandate considering SDLE, in addition to circadian drive, for coping with health consequences of atypical light exposure in our society.
Keywords
circadian and noncircadian, melanopsin, photoperiods, phototransduction, sleep–wake cycle
Pubmed
Web of science
Open Access
Yes
Create date
29/06/2021 9:33
Last modification date
24/07/2021 6:34
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