Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_81AA6FF34456
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0.
Journal
HIV medicine
Author(s)
Ryom L., Boesecke C., Bracchi M., Ambrosioni J., Pozniak A., Arribas J., Behrens G., Mallon P., Puoti M., Rauch A., Miro J.M., Kirk O., Marzolini C., Lundgren J.D., Battegay M.
Working group(s)
EACS Governing Board
Contributor(s)
d'Arminio Monforte A., Clumeck N., Dedes N., Gatell J.M., Horban A., Katlama C., McCormack S., Molina J.M., Mussini C., Raffi F., Reiss P., Stellbrink H.J., Bower M., Cinque P., Collins S., Compston J., De Wit S., Fabbri L.M., Fux C.A., Guaraldi G., Martínez E., Papapoulos S., du Pasquier R., Poulter N., Williams I., Winston A., Berenguer J., Bhagani S., Bruno R., Konov S., Lacombe K., Mauss S., Mendão L., Peters L., Rockstroh J.K., Fätkenheuer G., Furrer H., Mocroft A., Morlat P., Volny-Anne A.
ISSN
1468-1293 (Electronic)
ISSN-L
1464-2662
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
19
Number
5
Pages
309-315
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The European AIDS Clinical Society (EACS) Guidelines have since 2005 provided multidisciplinary recommendations for the care of HIV-positive persons in geographically diverse areas.
Major revisions have been made in all sections of the 2017 Guidelines: antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Newly added are also a summary of the main changes made, and direct video links to the EACS online course on HIV Management. Recommendations on the clinical situations in which tenofovir alafenamide may be considered over tenofovir disoproxil fumarate are provided, and recommendations on which antiretrovirals can be used safely during pregnancy have been revised. Renal and bone toxicity and hepatitis C virus (HCV) treatment have been added as potential reasons for ART switches in fully virologically suppressed individuals, and dolutegravir/rilpivirine has been included as a treatment option. In contrast, dolutegravir monotherapy is not recommended. New recommendations on non-alcoholic fatty liver disease, chronic lung disease, solid organ transplantation, and prescribing in elderly are included, and human papilloma virus (HPV) vaccination recommendations have been expanded. All drug-drug interaction tables have been updated and new tables are included. Treatment options for direct-acting antivirals (DAAs) have been updated and include the latest combinations of sofosbuvir/velpatasvir/voxilaprevir and glecaprevir/pibrentasvir. Recommendations on management of DAA failure and acute HCV infection have been expanded. For treatment of tuberculosis (TB), it is underlined that intermittent treatment is contraindicated, and for resistant TB new data suggest that using a three-drug combination may be as effective as a five-drug regimen, and may reduce treatment duration from 18-24 to 6-10 months.
Version 9.0 of the EACS Guidelines provides a holistic approach to HIV care and is translated into the six most commonly spoken languages.
Keywords
AIDS-Related Opportunistic Infections/drug therapy, Adult, Anti-Retroviral Agents/adverse effects, Anti-Retroviral Agents/therapeutic use, Antiretroviral Therapy, Highly Active/adverse effects, Antiretroviral Therapy, Highly Active/methods, Coinfection/drug therapy, Drug Interactions, Europe, Female, HIV Infections/drug therapy, Humans, Male, Practice Guidelines as Topic, Pregnancy, Pregnancy Complications, Infectious/drug therapy, Societies, Scientific, ART, European AIDS Clinical Society guidelines, HBV, HCV, HIV, antiretroviral treatment, coinfections, comorbidities, opportunistic diseases
Pubmed
Web of science
Open Access
Yes
Create date
25/08/2023 5:17
Last modification date
06/08/2024 6:02
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